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Spero Therapeutics Inc

SPRO

NASDAQ

Biotechnology

$1.23

USD

-0.01 (-0.81%)

At close: Aug 14, 2026, 4:00 PM EDT

Market Cap $72.09M

Volume 744.5K

Price (USD)
Price (USD)

About Spero Therapeutics Inc

Spero Therapeutics, Inc. is a clinical-stage biopharmaceutical company, which focuses on identifying, developing, and commercializing treatments involving bacterial infections, including multi-drug resistant bacterial infections, and rare diseases Its pipeline product candidates include Tebipenem HBr, SPR720, and SPR206. The company is headquartered in Cambridge, Massachusetts and currently employs 25 full-time employees. The company went IPO on 2017-11-02. The firm is focused on identifying and developing novel treatments for rare diseases and diseases caused by multi-drug resistant (MDR) bacterial infections with unmet need. Its product candidate SPR720 is an investigational, chemically stable phosphate ester prodrug that is converted in vivo to SPR719 for the treatment of nontuberculous mycobacterial (NTM) pulmonary disease. Its clinical stage product candidate, tebipenem HBr is an investigational oral carbapenem antibiotic being developed for the treatment of complicated urinary tract infections (cUTIs) including acute pyelonephritis (AP) to help patients potentially reduce duration of in-patient therapy.

CEO

Ms. Esther Rajavelu

HQ

Cambridge, MASSACHUSETTS, US

Founded

2017

Employees

25

Quantli Score

8.4

Outperform

Fin. Health

8.1

Profitability

7.6

Growth

9.0

Cash-Flow Q.

8.8

Key Metrics

6 metrics our research team weighs before forming a view on SPRO.

Based on Quantli research · SEC filings · as of Q1 2026

METRIC

VALUE

CHANGE

TREND (3Y)

Revenue Growth (TTM)

37.2%

+97.1 pp

Gross Margin (TTM)

100.0%

0.0 pp

Operating Margin (TTM)

22.1%

+188.3 pp

Net Margin (TTM)

24.9%

+181.4 pp

ROE (TTM)

28.8%

+235.1 pp

Free Cash Flow (TTM)

$7.24M

Financial Snapshot

Full Financials

Revenue

$61.19M

+37.2%

YoY

Gross Margin

100%

TTM

0.0%

YoY

Net Income

$15.23M

+121.8%

YoY

Operating Cash Flow

$7.24M

+121.7%

YoY

Key Statistics

Open

$1.26

Previous Close

$1.24

Day Range

$1.19 - $1.26

52 Week Range

$1.08 - $3.08

Volume

744.5K

Average Volume (10 Days)

770.0K

Dividend Yield

Valuation Measurement

Market Cap

$72.09M

P/E Ratio (TTM)

4.73

P/S Ratio (TTM)

1.18

Price / Book

1.36

Financial Highlights

Profit Margin

24.9%

Return on Assets

25.8%

Return on Equity

28.8%

Revenue (TTM)

$61.19M

Net Income (TTM)

$15.23M

Diluted EPS (TTM)

$0.17

Total Cash (MRQ)

$56.13M

Levered FCF (TTM)

$7.24M

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Swing Strategy

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Best for:

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Position Strategy

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Best for:

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Earnings Calendar

Next Earnings

Estimated Q3 Release

Nov 11

Est. EPS

Adjusted consensus estimate

-$0.16