Prime Medicine Inc
PRME
NASDAQ
Biotechnology
$3.09
USD
-0.08 (-2.52%)
At close: Aug 14, 2026, 4:00 PM EDT
Market Cap $574.96M
Volume 1.6M
About Prime Medicine Inc
Prime Medicine, Inc. is a biotechnology company, which engages in developing one-time curative genetic therapies. The company is headquartered in Cambridge, Massachusetts and currently employs 146 full-time employees. The company went IPO on 2022-10-20. The company deploys its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated one-time curative genetic therapies. The company is advancing a set of high-value programs across its core areas of focus (hematology, immunology and oncology, liver, and lung). These include ex vivo hematopoietic stem cell (HSC) programs for the treatment of p47phox chronic granulomatous disease CGD and X-linked CGD; a lipid nanoparticle (LNP) Prime Editor for the treatment of Wilson’s Disease; a LNP or adeno-associated virus Prime Editors for the treatment of cystic fibrosis; and ex vivo T-cell therapies. PM359, its product candidate within its hematology, immunology and oncology area of focus, targets the p47phox variant of CGD. Its PM577 comprises a Prime Editor encapsulated as RNA cargo in a liver-targeted LNP.
CEO
Dr. Allan Reine
HQ
Cambridge, MASSACHUSETTS, US
Founded
2022
Employees
146
Quantli Score
8.4
Outperform
Fin. Health
8.1
Profitability
7.6
Growth
9.0
Cash-Flow Q.
8.8
Key Metrics
6 metrics our research team weighs before forming a view on PRME.
Based on Quantli research · SEC filings · as of Q2 2026
METRIC
VALUE
CHANGE
TREND (3Y)
Revenue Growth (TTM)
-17.9%
-757.3 pp
Gross Margin (TTM)
100.0%
0.0 pp
Operating Margin (TTM)
-4824.9%
-708.4 pp
Net Margin (TTM)
-4613.1%
-596.3 pp
ROE (TTM)
-472.0%
-144.6 pp
Free Cash Flow (TTM)
$-156.85M
—
Financial Snapshot
Revenue
$4.07M
-17.9%
YoY
Gross Margin
100%
TTM
0.0%
YoY
Net Income
$-187.89M
+5.7%
YoY
Operating Cash Flow
$-156.05M
-56.2%
YoY
Key Statistics
Open
$3.14
Previous Close
$3.17
Day Range
$3.00 - $3.14
52 Week Range
$2.67 - $6.94
Volume
1.6M
Average Volume (10 Days)
2.6M
Dividend Yield
—
Valuation Measurement
Market Cap
$574.96M
P/E Ratio (TTM)
—
P/S Ratio (TTM)
141.16
Price / Book
14.44
Financial Highlights
Profit Margin
-4613.1%
Return on Assets
-75.4%
Return on Equity
-472.0%
Revenue (TTM)
$4.07M
Net Income (TTM)
$-187.89M
Diluted EPS (TTM)
-$1.10
Total Cash (MRQ)
$47.45M
Levered FCF (TTM)
$-156.85M
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Earnings Calendar
Next Earnings
Estimated Q3 Release
Nov 05
Est. EPS
Adjusted consensus estimate
-$0.25
Analyst Consensus
Based on 1 analyst ratings
Avg Target: $8.00
(+158.9% upside)
High: $8.00 · Low: $8.00
Strong Buy
0%
Buy
100%
Hold
0%
Sell
0%
Strong Sell
0%